Puppies from 2 months to 8 months can experience symptoms of HOD. This range is the range of highest growth rate in Great Dane puppies. Puppies with the most severe symptoms suffer from anorexia, weight loss, fever, and depression accompanied by extremely swollen, warm, and painful long-bone abnormalities. The pain can be so severe that they refuse to bear weight on the affected limbs. The symptoms can appear for approximately 1 week and then disappear reoccurring multiple times of a 6 week period.

Pano is a growth issue as a result of too rapid growth during puppyhood. It causes lameness and a lack of energy. Pano usually is self-limiting, meaning it ends up spontaneously resolving, but the condition is quite painful and pain medication and anti-inflammatory drugs may be needed.  These are painful conditions of the bones that occur during the rapid growth phase of puppyhood causing lameness and general malaise.